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Accelerate insights by connecting phenotype to genotype

The Bifrost platform connects single-cell phenotypes including morphology, protein localization and production, cellular responses, and cell-cell interactions to underlying alleles at massive scale. Integrated software allows rapid progression from experiment to massive multi-parameter dataset to actionable insights.

Link phenotypes and genes at unprecedented speed and scale to power efficient discovery

The Bifrost platform connects single-cell phenotypes including morphology, protein localization and production, cellular responses, and cell-cell interactions to underlying alleles at massive scale. Integrated software allows rapid progression from experiment to massive multi-parameter dataset to actionable insights.

How it works

Precision in
every nucleotide;
Insight from
every cell

Cellular features and functions (phenotype)
are encoded by each cell’s unique genetic code (genotype)

Image courtesy of Blainey Lab, Broad Institute of MIT and Harvard

50 million per week

 

single-cell phenotypes
linked to
genotypes

To better understand complex biological processes that lead to disease phenotypes, the Bifrost platform images and analyzes massive volumes of cells, connects each cell’s observed phenotype back to its genotype, and, through its advanced software analysis and machine learning/artificial intelligence algorithms, rapidly clusters related alleles and teases out significant insights that can transform early drug discovery decisions.
Explore the technology
  • 1/4

    De-risking drug development

    Drug development is expensive. Failures, even more so. And drug discovery is rife with failures. Armed with significantly more high-quality information earlier in the discovery phase, drug developers can kill doomed projects early and move winners forward more aggressively thereby reducing costs and getting critical drugs to market faster.

  • 2/4

    Better hits, faster

    Arrayed screening is robust and useful but slow and costly. Pooled screening brings the benefits of arrayed screening without the downsides. Our technology brings the power of high-resolution immunofluorescent imaging together with next generation sequencing technology in the same integrated platform to reliably and cost-effectively enable single-cell screening across tens of millions of cells.
  • 3/4

    Better data for everyone

    Our mission is to democratize access to optical pooled screening technology as the tool for understanding complex biological pathways and processes.
  • 4/4

    Enabling the future of medicine

    At Bifrost, we are delivering a tool to produce powerful insights with vast therapeutic implications. With example use cases ranging from elucidating targets for personalized medicine to combating the global threat of antibiotics resistance, our work is as deeply personal as it is expansive.

Single-cell biology expertise

Bifrost Leadership

The industry-leading Bifrost team is revolutionizing the next-generation of tools to decipher connections and regulatory pathways at the cellular level to propel novel biological discoveries. As foremost experts, Bifrost founders have been dedicated to this discipline for more than a decade and have built a team with a strong track record in operationalizing start-ups and accelerating development programs to commercial success.

About Bifrost